Along with Wendie Jo Sperber, McClure had been cast by Robert Zemeckis and Bob Gale in two earlier films, I Wanna Hold Your Hand (1978) and Used Cars (1980). Coincidentally, McClure had played characters named "Dubois" in both films.
He reprised the character of Dave McFly in Back to the Future Part II, but the scene (in which Marty encounters a drunken Dave in front of Biff's Pleasure Palace in the alternate 1985) was cut. He was brought back for Back to the Future Part III, where he was seen again as Marty's older brother Dave.
McClure made an appearance in the Superman series Smallville. His role in the Season 7 episode "Persona" (2008) saw him as a Kryptonian scientist Dax-Ur. He also appeared in the Season 7 DVD featurette Jimmy on Jimmy where he had a discussion with other actors who played the character Jimmy Olsen.
- Coincidentally, one of the songs Superman III is Earth Angel.
- In Back to the Future: The Game, "Citizen Brown", it's mentioned that Dave's 1986B counterpart left to work in a big city newspaper (referring to Marc's role as Jimmy Olsen).