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Bill Nye made his first appearance on the live-action segments of Back to the Future: The Animated Series, performing science experiments in the video encyclopedia that the viewers could try for themselves at home. He had a line in one episode of the show.
In 2013, Nye appeared as himself in an episode of The Big Bang Theory, "The Proton Displacement", as a new friend of Sheldon Cooper, only to later file a restraining order on him.