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Doc built the distillery in order to distill juniper berries to treat the infection in his dog Einstein's eyes. However, due to his haste in creating the makeshift distillery, Doc accidentally put the relief valve on backwards. Thus, the Acme pressure gauge on the distillery reaches critical, and the machine explodes.
Behind the scenes
The name Acme is a fictional brand that is used in the many products purchased by Wile E. Coyote to try to capture the Road Runner in the Looney Tunes cartoons. It was also used in Who Framed Roger Rabbit?, which was directed by Robert Zemeckis.